GC, Ҿ ȯ ġ ǰ 㰡 û

  • ã ߰
  • 2024.04.17() 17:22
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GC, Ҿ ȯ ġ ǰ 㰡 û
  • Է : 2022. 03.02() 10:59
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GCڴ 2 28 ǰǾǰó Ҿ ȯ ž 󸯽ù(Maralixibat) NDA ûߴٰ 2 .

󸯽ù 㵵 ϰ, üǴ Ҿ ȯ ˶ ı(ALGS)[1] ġ. ALGS ̽ ġ̴.

GCڴ 7 ̱ ̷ ĸƼý(Mirum Pharmaceuticals) 󸯽ù ȭ ̼ ü ִ.

󸯽ù 2019 ̱ ǰǾ౹(FDA) ġ(Breakthrough Therapy) ޾, 9 ALGS ü Ҿ ġ FDA ǰ 㰡 ޾Ҵ. ̷ Ǿǰû ǰ 㰡 ´. ̿ Բ ༺ ü(PFIC)[2] 㵵 (BA)[3] ALGS ̱ 㰡 ӻ Բ ϰ ִ.

GCڴ ̹ ALGS , ǰ 㰡 ȹ̴. 󸯽ù ȯ 忡 ž ޴ ȯڵ鿡 ο ȴ.

Ǿǰ ȯ ( α) 2 ȯ Ǵ ġ, ġ Ǿǰ ߵ ȯ ϰų ü Ǿǰ Ǵ ȿ Ǿǰ Ѵ. Ǿǰ ǾǰϽɻ(DMF) մ ִ ִ.

[1] ˶ ı(Alagille syndrome) 㵵 ϰ üǴ ȯ ǹѴ.
[2] ༺ ü(Progressive familial intrahepatic cholestasis) ⿡ ϴ ܹ ߻ϴ ü ǹѴ.
[3] 㵵 (biliary atresia) 㵵 ıǰų ̻ ܼ Ϻ Ǵ ΰ Ǵ ¸ ǹѴ.
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